The DL (i) addresses the penetration and proliferation of Industry 4.0-compliant and AI-supported ecosystems into the industrial environments under the perspective of a Circular Economy framework, taking into account that the same trend is also evident in other domains such as energy, healthcare, manufacturing, military, transportation, consumer, enterprise, robotics, and smart cities, among others; and (ii) offers an overview of major requirements for supporting the Engineering of Artificial Intelligence (AI)-based automation of processes and of the Systems-of-Cyber-Physical-Systems behind, showing examples of ongoing innovation projects and deployed solutions.