Industry 4.0-compliant systems are all Industrial Eco-Systems where components (Assets, Things) have been migrated into digitalized and networked Industrial Cyber-Physical Systems. This means, digitalized and networked assets are nodes of an Internet-based communication and information network. Each of those nodes is able to expose and/or consume digitalized data and information in the form of “services”, for performing new form of application and business based on Industrial Internet of Services Technology (IIoS). The structural and functional interdependences between those digitalized Asset, I4.0 components, Industrial-Internet-of-Things (IIoT) within an Industrial Eco-system are more evident if the “Digitalization process” is formally performed following the DIN Specification 91345 Reference Architecture Model for Industry 4.0 (RAMI4.0).